St. Joseph Regional School in Keene, New Hampshire is a private, Roman Catholic school serving students in the Keene Deanery of the Diocese of Manchester, NH.

St. Joseph Regional School has been Keene's Catholic school since its founding in 1887. St. Joseph Regional School provides education for the whole child in pre-school and grades K-8. The St. Joseph Regional School also offers an exceptional day care program from 8am to 5 pm on a year 'round basis.